Cutoff lensing: predicting catalytic sites in enzymes
نویسندگان
چکیده
منابع مشابه
Cutoff lensing: predicting catalytic sites in enzymes
Predicting function-related amino acids in proteins with unknown function or unknown allosteric binding sites in drug-targeted proteins is a task of paramount importance in molecular biomedicine. In this paper we introduce a simple, light and computationally inexpensive structure-based method to identify catalytic sites in enzymes. Our method, termed cutoff lensing, is a general procedure consi...
متن کاملThe Catalytic Site Atlas 2.0: cataloging catalytic sites and residues identified in enzymes
Understanding which are the catalytic residues in an enzyme and what function they perform is crucial to many biology studies, particularly those leading to new therapeutics and enzyme design. The original version of the Catalytic Site Atlas (CSA) (http://www.ebi.ac.uk/thornton-srv/databases/CSA) published in 2004, which catalogs the residues involved in enzyme catalysis in experimentally deter...
متن کاملElectrostatic origin of the catalytic power of enzymes and the role of preorganized active sites.
Enzymatic reactions are involved in most biological processes. Thus, there is a major practical and fundamental interest in finding out what makes enzymes so efficient. Many crucial pieces of this puzzle were provided by biochemical and structural studies (1). Yet, as will be shown below, the actual reason for the catalytic power of enzymes is not widely understood. It is clearly not explained ...
متن کاملPredicting SUMOylation Sites
Recent evidence suggests that SUMOylation of proteins plays a key regulatory role in the assembly and dis-assembly of nuclear subcompartments, and may repress transcription by modifying chromatin. Determining whether a protein contains a SUMOylation site or not thus provides essential clues about a substrate’s intra-nuclear spatial association and function. Previous SUMOylation predictors are l...
متن کاملCatalytic Active Sites in Molybdenum Based Catalysts
In situ metal, acid and metal-acid (bifunctional) catalytic active functions were prepared following partial reduction by hydrogen of MoO3 deposited on TiO2 at temperatures between 623 K and 673 K. The bifunctional structure is obtained following the reduction of MoO3 to MoO2. The metallic properties of MoO2 are attributed to the delocalized electrons above the Mo atoms place along the C-axis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep14874